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DRONTAL
| Active Ingredient | |
|---|---|
| Category | |
| Target Specificity | |
| Web Address | http://www.noworm.com |
| Mode of Action | Praziquantel: Praziquantel kills mature and immature development stages of tapeworms in the intestine after a single treatment. Within a few seconds of the tapeworm coming into contact with praziquantel its interaction with phospholipids and proteins causes damage to the tegument. The inflow of Ca+2Ions results in an immadiate contraction of the entire strobila. Moreover, these changes lead to a reduction of glucose intake and an accelerated depletion of energy reserves. Pyrantel embonate: Pyrantel, an anthelmintic of the Tetrahydropyrimidine group of compounds, acts in a similar way to levamisol, by inducing a depolarising neuromuscular blockade. Pyrantel, being a cholinergic agonist, acts as an excitatory neurotransmitter at the nicotinergic receptor causing spastic pralysis of the parasite. |
| Indication/Description | DRONTAL possesses an extremely wide spectrum of activity which covers infestation with the following cat nematodes and cestodes: Nematodes: Ascarids: - Toxocara cati - Toxascaris leonina Hookworms: - Ancylostoma tubaeforme - Ancylostoma braziliense Cestodes: - Echinococcus multilocularis - Dipylidium caninum - Taenia spp. - Joyeuxiella pasqualei - Mesocestoides spp. |
| CAS No | Praziquantel: 55268-74-1 Pyrantel embonate: 22204-24-6 |
| Chemical Name | Praziquantel:
2-(cyclohexylcarbonyl)-1,2,3,6,7,11b - hexahydro-4H-pyrazino(2,1-a) isoquinolin- 4-one Pyrantel embonate: (E)-1,4,5,6-tetrahydro-1-methyl-2- [2-(2-thienyl) ethenyl] pyrimidine and 4,4'-methylenebis [3-hydroxy-2-naphthalenecarboxylic acid (1:1) |
| Chemical Structure | Praziquantel: 
Pyrantel embonate:  |
| Method of Administration | The tablets are given orally to the animal, preferably concealed in a piece of meat, cheese, or titbit. No special dietary measures are required either in adult cats or in kittens. The product is given as a single dose (administration over several days is not necessary). |
| Dosage | 1 tablet per 4 kg bodyweight |