Efficacy against ticks

Ticks are, like fleas, among the most common and most important external parasites.
The most important species of hard ticks in Europe feeding on dogs are the Castor Bean tick (Ixodes ricinus) and the Brown Dog tick (Rhipicephalus sanguineus). Further species of the Dermacentor, Amblyomma or Haemaphysalis genera show only regional distribution.
Ticks are well designed to transmit disease agents such as viruses, bacteria and protozoa. Ixodes ticks are the major vectors of Lyme borreliosis, babesiosis and anaplasmosis. Rhipicephalus ticks may cause babesiosis and ehrlichiosis. These tick-borne diseases are of great concern both for canine and human health.
Laboratory-controlled studies conducted with I. ricinus, R. sanguineus and other tick species have proven the high acaricidal efficacy of advantix^®.
The figures show the persistent efficacy exceeding the four week period.

Persistent efficacy of advantix® against I. ricinus and R. sanguineus on dogs.

Efficacy of advantix® against the cat flea (Ctenocephalides felis) on dogs experimentally infested at weekly intervals.

advantix^®: Proven ability of preventing tick-borne diseases

While various tick control products have demonstrated their efficacy in killing ticks, little if at all is known about the ability of these products to prevent transmission of tick-borne diseases. Ticks of the Ixodes genus are worldwide the most important
vector of Borrelia burgdorferi to both dogs and humans.
advantix^® demonstrated its high effectiveness not only against ticks but also against the transmission of disease. Borrelia-free dogs were treated with advantix^® on day 0 and experimentally infested on day 7 with 100 Ixodes ticks with an average B. burgdorferi infectivity of 57%. Dogs were observed for seroconversion and Borrelia were counted in biopsy samples. By day 42 all control dogs showed seroconversion, as compared with none of the advantix^® treated dogs.
This study showed the ability of advantix^® to prevent canine Lyme borreliosis.

Arithmetic mean Borrelia burgdorferi antibody titers of dogs via kinetic ELISA showing the protential of advantix® to prevent transmission of tick-borne pathogens.